The Top five list...

Top five resident evil ennemies:

5.- First Zombie (RE 1)

Where all begins

4.- Tyrant T-003 (RE 2, RE DarkSide Chronicles )

Run Claire, run

3.- Doctor Salvador (RE 4)

A deadly and fast mother fucker

2.- Nemesis (RE 3)

He'll never give up

1.- Albert Wesker (Re 1, RE CV, RE 5 and others)

He used to work for a pharmaceutical, pure evil 

Bonus: Tofus (RE DarkSide Chronicles)

The people who had played RE DSC know how hard are they